Disease mechanisms

Our goal is to uncover the basic mechanisms of human disease. In particular, we are focusing on modern diseases whose incidence has greatly increased over the last decades, including metabolic, inflammatory, and neurodegenerative diseases. The etiology of these diseases cannot be explained solely by human genetics.

Our research is aimed at understanding the mechanistic impact of environmental influences on human physiology, and how such host-environment interactions influence the propensity for common multifactorial diseases.

Molecular phenotyping

We are developing and employing methods for the comprehensive analysis of cellular processes, including genomics, transcriptomics, and metabolomics.

We are using these molecular phenotyping strategies to generate insights into the mechanisms underlying biological phenomena, and to inform mechanistic studies of human disease. Additionally, we are using high-throughput screening approaches to elucidate the impact of specific environmental elements on the metabolic, immune and nervous system of the host.

We are using a large number of animal models for human disease and are generating new transgenic models for our studies.

Our focus is on inflammatory, metabolic, and neurodegenerative diseases.

We use a large range of animal phenotyping platforms, including imaging, metabolic and behavioral testing.