New paper on hyperglycemia and barrier dysfunction in Science
We have discovered that hyperglycemia drives dysfunction of the intestinal barrier, thereby promoting microbiota translocation and pathogenic infection in metabolic disease.
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A large number of common human diseases, including inflammatory and autoimmune diseases, neurodegeneration, metabolic diseases and cancer, are strongly influenced by environmental factors, including dietary nutrients, microorganisms, xenobiotics, light, temperature, and physical activity.
A major challenge in biology and medicine is to understand how these environmental factors are sensed by the metabolic, immune and nervous system, and how their integrative activity controls tissue homeostasis and inflammation. We are exploring this fascinating interface between the inside and outside world of the human body, using a combination of unbiased high-throuput technologies and hypothesis-driven approaches in both animal models of disease and human cohorts.