Trem2 drives lipid-associated macrophages (Cell, 2019)
We have discovered lipid-associated macrophages in adipose tissue, which are regulated by the lipid sensor Trem2 and promote metabolic homeostasis during obesity.
We have discovered lipid-associated macrophages in adipose tissue, which are regulated by the lipid sensor Trem2 and promote metabolic homeostasis during obesity.
The microbiome and microbiome-derived metabolites are involved in several features by which common human lifestyle elements predispose to obesity and diabetes.
We have discovered that hyperglycemia drives dysfunction of the intestinal barrier, thereby promoting microbiota translocation and pathogenic infection in metabolic disease.
We have discovered “memory-like” properties in the microbiome and its metabolites which mediate the tendency for weight regain after successful dieting.
We discovered multiple layers of circadian host-microbiome interactions, their effects on the orchestration of circadian biology of the host, and their consequences on metabolism.
Using single-cell genomics and epigenetics, we have identified interactions between the intestinal microbiome and innate lymphoid cells in the intestinal lamina propria.
A large number of common human diseases, including inflammatory and autoimmune diseases, neurodegeneration, metabolic diseases and cancer, are strongly influenced by environmental factors, including dietary nutrients, microorganisms, xenobiotics, light, temperature, and physical activity.
A major challenge in biology and medicine is to understand how these environmental factors are sensed by the metabolic, immune and nervous system, and how their integrative activity controls tissue homeostasis and inflammation. We are exploring this fascinating interface between the inside and outside world of the human body, using a combination of unbiased high-throuput technologies and hypothesis-driven approaches in both animal models of disease and human cohorts.