The microbiome integrates the influence of numerous environmental influences and thus serves as an important rheostat for the adaptation of physiology to the outside world. We study the dynamics of the microbiome in response to changes in environmental conditions, and how these microbiome dynamics influence host biology.
A large number of environmental impacts are undergoing rhythmic oscillations in a 24-hour rhythm, due to our planets rotation around its own axis. We are investigating how these diurnal fluctuations are integrated into physiological responses and how disturbances in these rhythms are involved in human disease.
Metabolites derived from dietary and xenobiotic compounds are among the most numerous molecules in the gastrointestinal tract. We are developing strategies to decipher the impact of nutrients and xenobiotics on human health and disease. We believe that these metabolites present ideal targets for powerful and innovative therapies.
Metabolism controls a large number of cellular and organismal responses. We are studying the control mechanisms of metabolic processes, and how metabolism in turn regulates cellular and organismal function.
The immune system controls immune and non-immune sensing functions alike, and plays a major role in tissue homeostasis, regeneration, and host defense. We study how immune cells interaction with non-immune cells and how such interactions are involved in chronic inflammatory diseases.
The nervous system is the major sensing organ of the body. We aim at elucidating the mechanisms by which the nervous system senses environmental impacts and how these sensing events are translated into regulatory circuits of human physiology.