The microbiome and microbiome-derived metabolites are involved in several features by which common human lifestyle elements predispose to obesity and diabetes.
We have discovered that hyperglycemia drives dysfunction of the intestinal barrier, thereby promoting microbiota translocation and pathogenic infection in metabolic disease.
We have discovered “memory-like” properties in the microbiome and its metabolites which mediate the tendency for weight regain after successful dieting.
We discovered multiple layers of circadian host-microbiome interactions, their effects on the orchestration of circadian biology of the host, and their consequences on metabolism.
Using single-cell genomics and epigenetics, we have identified interactions between the intestinal microbiome and innate lymphoid cells in the intestinal lamina propria.
The intestinal microbiome exerts a major immunomodulatory effect, in particular the innate immune system. This has a strong impact on health and disease.